In Nightwatch the sequel, Emma, a medical student, takes on a nightwatch job in the forensic department. And it is no coincidence. Since the fatal night-30 years earlier, when psychopathic inspector Wörmer almost killed Emma's parents, who were saved at the very last minute by their friend Jens, her family has been haunted by this horrific memory. Her mother Kalinka, actually committed suicide when Emma was 10 and her father Martin is still the shadow of himself. The young woman decides to investigate what happened in her parents’ past. Upon meeting with Wörmer, Emma wakes him from his coma, and unintentionally initiates a bloody revenge on all of those who sealed Wörmer’s destiny.
When a creepy Jack-in-the-Box is discovered and opened on the grounds of an exclusive girls' school, six brave students soon enter a fight to the finish against the unleashed demon.
After realising he has died at the scene of a car crash, Nathan descends into the depths of hell, where he is doomed to experience the pain of tortured souls along the way.